![]() This is attributable to the decrease in the average absorbed dose in some OARs when using IMRT technique. RESULTS: Lifetime risk of secondary cancer for CSI pediatric patients treated using IMRT decreases in some OARs compared with those treated using 3D-CRT. ![]() The average lifetime risk of radiation-induced secondary cancer was then calculated. The average absorbed doses for organs at risk (OARs) was calculated from dose-volume histograms on the treatment planning system. MATERIALS AND METHODS: 3D-CRT and IMRT plans were performed for 10 CSI pediatric patients. The aim of this study was to estimate and compare the lifetime risk of radiation-induced secondary cancer in pediatric medulloblastoma patients using three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT). Talk with your health care provider for advice.BACKGROUND: Craniospinal irradiation (CSI) is the standard radiation therapy treatment for medulloblastoma. These studies provide a chance to try the latest treatment options, though the risk of side effects may not be known. Clinical trials enroll eligible participants to study new treatments or to study new ways of using existing treatments, such as different combinations or timing of radiation therapy and chemotherapy. Sometimes it's done at the same time as radiation therapy. Chemotherapy may be used after surgery or radiation therapy. Typically, children and adults with medulloblastoma receive these medicines as an injection into veins. Chemotherapy uses medicines to kill cancer cells. Radiation therapy is often used after surgery. During radiation therapy, a machine directs beams of energy to specific points on the body. The energy can come from X-rays, protons and other sources. ![]() Radiation therapy uses powerful energy beams to kill cancer cells. Most people with medulloblastoma need more treatments after surgery to kill any cancer cells that are left. But sometimes it's not possible to fully remove the tumor because it forms near important structures deep within the brain. The goal of surgery is to remove all of the medulloblastoma.
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